Microbiology Talk- MiTalk

Episode 4- Basics of Hepatitis C Virology Recording Time: 19th September, 2016 Topic: Basics of Hepatitis C Virology Episode Highlights: 1. Classification of Hepatitis virus and Structure of Hepatitis C Virus Classification or Types (A, B, C, D and E) Structure and Genome of Virus 2. Genotypes and Epidemiology statistics Genotypes Epidemiology World, USA, South-East Asia, India, Nepal 3. Pathogenesis and Life cycle Mechanism of transmission Cellular entry and replication mechanism Viral evasion and restriction factors 4. Laboratory diagnosis, prevention and treatment of Hepatitis C References Scheel TKH and Rice CM. Understanding the hepatitis C virus life cycle paves the way for highly effective therapies. Nature Medicine. 2013;19(7):837-849. Manns Mvon Hahn T. Novel therapies for hepatitis C — one pill fits all?. Nature Reviews Drug Discovery. 2013;12(8):595-610.

Episode 3- Indigenous Leprosy vaccine and its implications Recording Time: 2nd September, 2016; 8:00 pm IST Topic: Indigenous Leprosy vaccine and its implications Episode Highlights: Leprosy- Basic biology Statistics of Leprosy- Brief History Global Statistics Why do we need a Leprosy vaccine ? Logic of using Mycobacterium indicus pranii (MIP) for making a vaccine Current status of Indigenously developed Leprosy vaccine References and links: Leprosy. An Update. http://www.actasdermo.org/en/leprosy-an-update-definition-pathogenesis/articulo/S1578219013001431/ Leprosy: An Overview of Pathophysiology. http://www.hindawi.com/journals/ipid/2012/181089/ Yadava A et al. T-Cell Responses to Fractionated Antigens of Mycobacterium w, a Candidate Anti-Leprosy Vaccine, in Leprosy Patients. Scand J Immunol. 1991;34(1):23-31. Sharma et al. Immunoprophylactic effects of the anti-leprosy Mw vaccine in household contacts of leprosy patients: clinical field trials with a follow up of 8-10 years. Lepr Rev. 2005 Jun;76(2):127-43

Episode 2- Talking about Zika Virus Recording Time: 5th August, 2016; 8:00 pm IST Topic: Talking about Zika Virus Episode Highlights: 1. Basic Biology Identification History Structure and genetic make up Earlier epidemiological situations Current epidemiology- Asian context and Global context 2. Animal models for Zika research 3. Treatment and vaccine strategies 4. Microcephaly and Zika virus correlation References and links: Zika Virus. Clinical Microbiology reviews. Doi: 10.1128/CMR.00072-15 Zika Virus. NEJM. Doi: 10.1056/NEJMra1602113 Zika virus: Indian perspectives. Doi: 10.4103/0971-5916.187103 Broadly neutralizing activity of Zika virus-immune sera identifies a single viral serotype. Cell Reports, 2016 DOI: 10.1016/j.celrep.2016.07.049 Zika virus challenges for neuropsychiatry. Neuropsychiatric Disease and Treatment, 2016; Volume 12: 1747 DOI: 10.2147/NDT.S113037 Zika Virus- Structure, Genome, Symptoms, Transmission, Pathogenesis, Diagnosis. Accessed From: http://www.microbiologyinfo.com/zika-virus-structure-genome-symptoms-transmission-pathogenesis-diagnosis/ Mapping global environmental suitability for Zika virus. https://elifesciences.org/content/5/e15272

Episode 1- Hidden mechanisms for Biofilms against antibiotics Recording Time: 26th July 2016; 8:00 pm IST Topic: Biofilms and antibiotic resistance mechanism Episode Highlights: Basic understanding of biofilm Structure of  biofilm Steps in a formation of a biofilm Problems associated with biofilms in clinical settings How a biofilm protects against antibiotics Physical barrier Efflux pump Antibiotics as biofilm signals Current state of research on drugs that can target biofilm Anti-Biofilm strategies that are under investigation- Bactericidal strategies, anti adhesion strategies, Modulation of dispersing signals. Acyldepsipeptides (ADEPs) References and links: Bacterial biofilms: development, dispersal, and therapeutic strategies in the dawn of the postantibiotic era. http://www.ncbi.nlm.nih.gov/pubmed/23545571 Biofilms: Microbial Shelters Against Antibiotics. http://www.ncbi.nlm.nih.gov/pubmed/27214143 Activated ClpP kills persisters and eradicates a chronic biofilm infection.http://www.ncbi.nlm.nih.gov/pubmed/24226776 Strategies for combating bacterial biofilm infectionshttp://www.nature.com/ijos/journal/v7/n1/full/ijos201465a.html Polysaccharide-based antibiofilm surfaces. Acta Biomaterialiahttp://www.sciencedirect.com/science/article/pii/S1742706115301872 BtB#8- Resistance, Persistence and Tolerance http://varuncnmicro.blogspot.in/2013/11/acyldepsipeptides-adeps-active-against.html