NEUROSCIENTISTS TALK SHOP

On February 26, 2026 we were joined by Dr. Peter Fox to talk about quantitative brain imaging methods and how they can reveal localized changes in brain structure in brain disorders that traditionally have not been associated with specific neuropathology. Guest: Peter Fox, Director, Brain Imaging Institute and Professor of Radiology, Neurology, and Physiology at UT Health San Antonio. Participating: George Perry, Department of Neuroscience, Developmental and Regenerative Biology, UTSA. Host: Charles Wilson, Department of Neuroscience, Developmental and Regenerative Biology, UTSA.

On February 19, 2026 we were visited by Dr. Dayu Lin to hear about her work on some of the cell groups that make up the hypothalamus and their function in activating innate social behaviors in mice, including parenting and protection of their young. Guest: Dayu Lin, Professor in the Departments of Psychiatry and Neuroscience, Institute for Translational Neuroscience, Langone Medical Center, New York University Participating: Antony Burgos-Robles, Department of Neuroscience, Developmental and Regenerative Biology, UTSA. Aayushma Kunwar, Department of Neuroscience, Developmental and Regenerative Biology, UTSA. Host: Charles Wilson, Department of Neuroscience, Developmental and Regenerative Biology, UTSA. Thanks to James Tepper for original music.

On February 5, 2026 we met with Dr.Jonathan Bohmann to learn about the structure and function of acetylcholinesterase, the extracellular enzyme that controls the strength and time course of neurotransmitter at cholinergic synapses. He explained how computational models of molecular structure is be used to understand the functional properties of the enzyme and to design drugs that can modify its action. Guest: Jonathan Bohmann, Scientist, Southwest Research Institute, San Antonio Participating: Jenny Hsieh, Department of Neuroscience, Developmental and Regenerative Biology, UTSA Host: Charles Wilson, Department of Neuroscience, Developmental and Regenerative Biology, UTSA

On January 30, 2026, Fidel Santamaria returned to the podcast (after 18 years) to talk about the thermodynamics of ion channel activation and deactivation, and the changes in neuronal activity that occur with changes in temperature. Guest: Fidel Santamaria, Professor, Department of Neuroscience, Developmental and Regenerative Biology. Host: Charles Wilson, Department of Neuroscience, Developmental and Regenerative Biology. Thanks to Jim Tepper for original music

On December 8, 2025 we spoke with Dr. Matthew Goodwin about the use of wearable biosensor technology and machine learning to improve behavioral evaluation of autism, to provide real time alerts for caregivers and more effective interventions before the onset of potentially dangerous behavioral situations. Guest: Matthew Goodwin, Professor and Associate Chair of Research at the Department of Public Health and Health Sciences and the Khouri College of Computer Sciences, at Northeastern University. Participating: Leslie Neeley, Director of the Child and Adolescent Policy Research Institute, and Associate Director of the Brain Health Consortium, UTSA Host: Charles Wilson, Department of Neuroscience, Developmental and Regenerative Biology, UTSA Thanks to James Tepper for original music

On December 4, 2025 we talked with Dr. Mike Beckstead about his work on changes in dopaminergic neuron excitability in the ventral tegmental area in an animal model of Alzheimer's disease. Mike explained the molecular mechanism of the excitability change and the change in gene expression at its cause. Guest: Mike Beckstead, Professor and Hille Family Foundation Chair in Neurodegenerative Disease Research, Aging & Metabolism Research Program Oklahoma Medical Research Foundation Participating: Matt Wanat, Department of Neuroscience, Developmental and Regenerative Biology, UTSA Host: Charles Wilson, Department of Neuroscience, Developmental and Regenerative Biology, UTSA Thanks to James Tepper for original music

On November 20, 2025 we met with Dr. Cristian Lasagna-Reeves to talk about tau protein, its normal function, and what is known about how it aggregates to form the tangles seen in a variety of neurodegenerative brain conditions. We discussed the problem of determining whether the aggregates were causes or effects of the disease process, and whether reducing expression of tau might be an effective treatment. Guest: Cristian Lasagna-Reeves, Associate Professor, Dept. of Neurology, Baylor College of Medicine Participating: George Perry, Department of Neuroscience, Developmental and Regenerative Biology, UT San Antonio Hyoung-gon Lee, Department of Neuroscience, Developmental and Regenerative Biology, UT San Antonio Host: Charles Wilson, Department of Neuroscience, Developmental and Regenerative Biology, UT San Antonio Thanks to Jim Tepper for original music

On November 13, 2025, we met with Dr. Maria Diehl, to learn about her experiments on avoidance learning in rats. The conversation focused on learning in a social context, in which one animal benefits from watching another learn the task. We had to relocate this week, because of a noisy construction project in the hallway outside our usual room. Guest: Maria Diehl, Associate Professor in Psychological Science, Kansas State University. Participating: Tony Burgos-Robles, Department of Neuroscience, Developmental and Regenerative Biology, UTSA Itamar Lerner, Department of Psychology, UTSA Host: Charles Wilson, Department of Neuroscience, Developmental and Regenerative Biology, UTSA Thanks to Jim Tepper for original music

On November 6, 2025, I spoke with Dr. Jason O'Connor about the behavioral and psychological effects of inflammation, and their similarity to depression. Jason explained how inflammation can produce those symptoms by increasing levels of kynurenine and metabolites in the brain. We discussed the possibility that depression may sometimes result from a rise in those metabolites in the absence of inflammation. Guest: Jason O'Connor, Associate Professor of Pharmacology at the UT San Antonio Long School of Medicine and the Audie Murphy VA Hospital. Host: Charles Wilson, Department of Neuroscience, Developmental and Regenerative Biology, UT San Antonio Thanks to James Tepper for original music

On October 23, 2025 we met with Dr. Peter Crino about how mutations occurring during cell division in the developing cerebral cortex can lead to localized developmental malformations of cortical structure and neurological disorders including focal epilepsy. Guest: Peter Crino, Richard and Kathryn Taylor Professor, Chair, Department of Neurology, University of Maryland School of Medicine. Participating: Jenny Hsieh, Department of Neuroscience, Developmental and Regenerative Biology, UT San Antonio. Host: Charles Wilson, Department of Neuroscience, Developmental and Regenerative Biology, UT San Antonio.

On October 16, 2025 we spoke with Sara Swinford-Jackson about effects of parental drug self-administration on motivated drug taking in offspring in rodents. Sarah discussed the approach taken to remove genetic and environmental contributions to isolate the epigenetic contribution, and to identify the biological mechanism. Guest Sarah Swinford-Jackson, Assistant professor of Behavioral and Cellular Neuroscience in the Department of Psychological and Brain Sciences, Texas A&M University. Participating: Matt Wanat, Department of Neuroscience, Developmental and Regenerative Biology, UT San Antonio. Alexey Soshnev, Department of Neuroscience, Developmental and Regenerative Biology, UT San Antonio. Ashley Miller, Department of Neuroscience, Developmental and Regenerative Biology, UT San Antonio. Host: Charles Wilson, Department of Neuroscience, Developmental and Regenerative Biology, UT San Antonio. Thanks to James Tepper for original music

On October 9, 2025 we met with Maria Geffen to discuss the how three kinds of inhibitory neurons in the auditory cortex each contributes to individual features of auditory experience. Guest: Maria Geffen, Professor of Otorhinolaryngology, Neuroscience, and Neurology, University of Pennsylvania Participating: Alfonso Apicella, Department of Neuroscience, Regenerative and Developmental Biology, UTSA Alice Bertero, Department of Neuroscience, Regenerative and Developmental Biology, UTSA Jon-Paul Moler, Department of Neuroscience, Regenerative and Developmental Biology, UTSA Host: Charles Wilson, Department of Neuroscience, Regenerative and Developmental Biology, UTSA Thanks to James Tepper for original music

On October 2, 2025 Dan Lodge returned to the podcast to talk about the physiological changes in brain circuits associated with schizophrenia. We reviewed the status of the dopamine hypothesis of schizophrenia and the brain circuits responsible for its negative, positive, and cognitive symptoms. Guest: Dan Lodge, Professor and Chair, Department of Pharmacology, Long School of Medicine, UT San Antonio Participating: Matt Wanat, Department of Neuroscience, Developmental and Regenerative Biology, UT San Antonio Host: Charles Wilson, Department of Neuroscience, Developmental and Regenerative Biology, UT San Antonio Thanks to Jim Tepper for original music

On September 25, 2025 we met with Daniel Dombeck to talk about cognitive maps and place coding by neurons in the hippocampus. Conversation topics included the spatial organization of cells with a map, mappings based on visual versus olfactory cues, changes in spatial scale with the size of the environment, and remapping of the place cells with changes in context. Guest: Daniel Dombeck, Professor, Department of Neurobiology, Northwestern University Participating: Francesco Savelli, Department of Neuroscience, Developmental and Regenerative Biology, UTSA Stephen Jones, Department of Neuroscience, Developmental and Regenerative Biology, UTSA Host: Charles Wilson, Department of Neuroscience, Developmental and Regenerative Biology, UTSA Thanks to James Tepper for original music

On September 18, 2025, and we got to talk with Ricardo Mozzachiodi about what was learned and what we continue to learn about the cellular and molecular basis of memory by studying simple behaviors in a mollusk, Aplysia california, the sea hare. Ricardo filled us in on the original rationale for studying cell biology of learning in this animal, and current findings on the role of neuromodulators in learning. Guest: Ricardo Mozzachiodi, Professor, Department of Life Sciences, Texas A&M University, Corpus Christi. Participating: Alfonso Apicella, Department of Neuroscience, Developmental and Regenerative Biology, UTSA Host: Charles Wilson, Department of Neuroscience, Developmental and Regenerative Biology, UTSA Thanks to James Tepper for original music

On September 4, 2025 we talked with Michael Roberts about exploring complex brainstem circuitry of the auditory system, identifying its characteristic cell types, connections, synaptic features and cellular dynamics. We discussed the challenges encountered in studying brain circuits in general, and the particular difficulties and opportunities that attend this effort in the inferior colliculus. Guest: Michael Roberts, Associate Professor, Department of Otolaryngology-Head and Neck Surgery, and the Department of Molecular and Integrative Physiology at the University of Michigan. Participating: Marina Silveira, Department of Neuroscience, Developmental and Regenerative Biology, UTSA Host: Charles Wilson, Department of Neuroscience, Developmental and Regenerative Biology, UTSA Thanks to James Tepper for original music

On May 8, 2025 we met with Kevin Bieniek to talk about the nature of brain injury seen in chronic traumatic encephalopathy in athletes and others who experience repeated concussion. Kevin explained the commonalities and unique features of those injuries compared to neurodegenerative diseases. Guest: Kevin Bieniek, Associate Professor, Department of Pathology and Laboratory Medicine and Director of the Brain Bank at the Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases at UT Health San Antonio. Participating: Melanie Carless, Department of Neuroscience, Developmental and Regenerative Biology, UTSA Host: Charles Wilson, Department of Neuroscience, Developmental and Regenerative Biology, UTSA Thanks to James Tepper for original music

On April 17, 2025 we met with Nicholas Priebe to describe developments in the study of neuronal representations of the visual world. We discussed the origin of variability the temporal patterns of responses, and the possibility that responses are influenced by non-visual pathways. Guest: Nicholas Priebe, Department of Neuroscience, University of Texas at Austin Participating: Todd Troyer, Department of Neuroscience, Developmental and Regenerative Biology, UTSA Host: Charles Wilson, Department of Neuroscience, Developmental and Regenerative Biology, UTSA

On April 10th (I said April 4th, but it was the 10th), 2025 we spoke with Punam Pokam about the molecular mechanisms that control osmotic balance of neurons and glia, and their changes after brain injury. She also explained the pathological membrane potential changes and ionic currents that are associated with injury and their relation to cell swelling. Guest: Punam Pokam, Assistant Professor, Department of Neuroscience and Experimental Therapeutics, Texas A&M School of Medicine Host Charles Wilson, Department of Neuroscience, Developmental and Regenerative Biology, UTSA Thanks to James Tepper for original music

On April 3, 2025 we met with Lorena Saelices to talk about what we know about the structure of amyloids, how they form by misfolding and aggregation of proteins, and how they damage cells and tissues in a range of disorders (including Alzheimer's and Parkinson's diseases). Guest: Lorena Saelices, Assistant Professor, Department of Biophysics and the Center for Alzheimer's and Neurodegenerative Diseases at the UT Southwestern Medical School. Participating: Chris Gamblin, Department of Neuroscience, Developmental and Regenerative Biology, UTSA Host: Charles Wilson , Department of Neuroscience, Developmental and Regenerative Biology, UTSA Thanks to James Tepper for original music