Sounds Physiological

A conversation with Karl Magleby on short-term synaptic plasticity, discovering BK, and viewing things the way a channel does. Download PDF transcript Key words: synaptic plasticity, facilitation, augmentation, potentiation, BK, calcium-activated K channel

A conversation with Dick Tsien on moving from cardiac physiology to LTP in a half-dozen years, conformational signaling by channels, and being a physiologist in the UK when Hodgkin, Huxley, and Katz were all doing experiments Download PDF transcript Key words: cardiac physiology, neuroscience, LTP, calcium channels, N-type channels, Denis Noble, Alan Hodgkin

A conversation with Henry Lester on nicotinic acetylcholine receptors, inside-out pharmacology, teaching MOOCs, and Richard Feynman’s thoughts about single-channel recording. Download PDF transcript Key words: nicotine, nAChR, nicotinic receptor, inside-out pharmacology, MOOCs

A conversation with Don Bers on calcium signaling and compartmentation in cardiac myocytes. Download PDF transcript Key words: calcium, cardiomyocytes, cardiac contractility, calcium compartmentation, arrhythmias, CaM kinase

A conversation with Eduardo Ríos on post-Hodgkin thought, the voltage sensor in EC coupling, calcium sparks, and the university system in Uruguay. Download PDF transcript Key words: dihydropyridine receptor, ryanodine receptor, calcium sparks, cardiac muscle, skeletal muscle, calcium sparks, excitation-contraction coupling, calsequestrin

A conversation with Paul Greengard on “hormonal” communication between nerve cells, the biochemical bases by which antidepressants work, and the Pearl Meister Greengard Prize for outstanding women in biomedical research. Download PDF transcript Key words: second messengers, protein phosphorylation, slow synaptic transmission, protein kinases, cGMP, cAMP, synapsin I, serotonin, dopamine, p11, annexin A2, SMARCA3

A conversation with Chris Miller on channels, transporters, radical reductionism, and trusting your sense of scientific aesthetics. Download PDF Transcript Key words: ion channels, ion transporters, biophysics, ClC, chloride, fluoride, Fluc, lipid bilayers

A conversation with Richard Lewis on electrical resonance in hair cells, channels and signals in T cells, papayas in the lab, and following your nose. Download PDF transcript Key words: calcium, T cell, Hair cell, Papain, Orai, STIM, CRAC channels

A conversation with Barbara Ehrlich on calcium signaling, interpreting Truth, and what’s wrong with green apple-wasabi sorbet. Download PDF transcript Key words: calcium, IP3 receptor, ryanodine receptor, polycystin-2, paramecium, molecular hermeneutics, taxol, lithium, NCS-1, peripheral neuropathy

A conversation with David Clapham, on where scientific curiosity can take you. Download PDF transcript Key words: calcium, sperm, mitochondria, cilia, TRPM7, GPCRs, CRAC, noise analysis, patch clamp, channels

A conversation with Tullio Pozzan on calcium compartmentation and dynamics, and signaling between the mitochondria and the ER. Download PDF transcript Key words: calcium, cAMP, mitochondria, endoplamic reticulum, calcium indicators

A conversation with Brian Salzberg on using optical methods to measure membrane voltage, calcium, and neuropeptide secretion. Download PDF transcript Key Words: Potentiometric dyes; voltage-sensitive dyes;  arsenazo III, merocyanine-540, posterior pituitary, neurohypophysis, exocytosis, birefringence, secretion, chlorophyll, phototoxicity; squid

A conversation with Bertil Hille, who has devoted many years to investigating ion channel regulation, and permeability mechanisms. Download PDF Transcript Key Words:  Ion channel, permeability, frog, nerve, muscle, GPCRs, local anesthetics

A conversation with Baron Chanda, winner of the 2013 Paul F. Cranefield Award Download PDF transcript Key Words:  Ion channel, gating, voltage-clamp fluorimetry, thermodynamics, allosteric linkage

A conversation with Clay Armstrong, who has devoted many years to investigating ion channel permeability mechanisms and gating processes, and Clara Franzini Armstrong, who has spent many years investigating the structural bases of excitation–contraction coupling. Download PDF transcript Key words: Ion channel, gating, neuroscience, squid, TEA, muscle, excitation-contraction coupling, electron microscopy