UsAgainstAlzheimer's Podcast

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BrainStorm wants to hear from you! Send us a text. Alzheimer's disease is no longer just a memory problem — it's a biological, cultural, and ethical challenge reshaping how we think about aging, identity, and medicine. In this episode of Brainstorm by UsAgainstAlzheimers, host Meryl Comer sits down with Dr. Jason Karlawish, professor of medicine, medical ethics, health policy, and neurology at the University of Pennsylvania. They explore how Alzheimer's evolved from a rare condition into a full-blown public health crisis. Dr. Karlawish unpacks the science behind biomarker testing and early detection, the promise and complexity of new anti-amyloid treatments, and why so many physicians remain reluctant to diagnose cognitive decline at all. From health equity gaps that leave Latino and African American patients chronically underserved, to the ethical weight of disclosing an Alzheimer's diagnosis to someone still in the middle of their career, Dr. Karlawish brings both scientific precision and moral seriousness to one of medicine's most urgent conversations. It's a candid, wide-ranging discussion about what it truly means to confront a disease that strikes at the heart of who we are. You don’t want to miss this episode! Produced by Susan Quirk Support the show

BrainStorm wants to hear from you! Send us a text. In honor of Black History Month, this episode of BrainStorm by UsAgainstAlzheimer’s explores the critical intersection of Alzheimer's disease and health equity in African-American communities. Host Meryl Comer talks with Daphne Delgado, Vice President for Health Equity at UsAgainstAlzheimer's, and Dr. Charlene Whitaker-Brown, a clinical nursing professor and 2022 Brain Health Equity Nurse Fellowship graduate. They discuss the stark disparities facing Black Americans—who are twice as likely to develop Alzheimer's yet 35% less likely to receive timely diagnosis. Dr. Whitaker-Brown shares her powerful journey from experienced nurse to full-time caregiver, and how the fellowship transformed her ability to serve her community through culturally tailored outreach in churches, workshops, and community centers.  The conversation emphasizes the vital role nurses play as trusted frontline educators in promoting brain health, addressing stigma, and connecting families to essential resources. This is a must listen episode! Produced by Susan Quirk Support the show

BrainStorm wants to hear from you! Send us a text.  This episode of BrainStorm, by UsAgainstAlzheier’s, features host Meryl Comer interviewing Leah Fisher, a psychotherapist and author who took a bold year-long solo travel sabbatical at age 60 to explore different cultures while maintaining her marriage. The conversation takes a poignant turn as Fisher reveals that after the events in her book, she received an MCI (Mild Cognitive Impairment) diagnosis with elevated Alzheimer's risk. She candidly shares her journey of recognizing early symptoms like misplacing car keys and developing aphasia, the validation that came with diagnosis, and her current experience living with uncertainty about disease progression. Fisher offers insights on how couples cope with health diagnoses, the importance of curiosity over avoidance, and her desire to be treated with patience, kindness, and continued love as she faces an uncertain future. Support the show

BrainStorm wants to hear from you! Send us a text. BrainStorm guest Vradenburg, Chairman and Founder of UsAgainstAlzheimer's, sits down with host Meryl Comer for a comprehensive look at the state of Alzheimer's research, advocacy, and care in 2025. Vradenburg addresses critical challenges facing the Alzheimer's community, including threats to NIH funding and the impact of funding instability on researchers and clinical trials. The discussion covers key advocacy efforts like the CHANGE Act and ASAP Act, which aim to make cognitive checkups and blood-based diagnostic tests more accessible through Medicare coverage. Vradenburg also highlights UsAgainstAlzheimer's expanding initiatives, from the BrainGuide platform offering direct-to-consumer cognitive assessments to educational programs training healthcare professionals on brain health. Looking forward, Vradenburg makes a bold prediction: within the next decade, we could see preventive treatments for Alzheimer's, potentially including a vaccine. This episode offers both a candid assessment of current challenges and an optimistic vision for the future of Alzheimer's prevention and treatment. This is a must listen episode! Produced by Susan Quirk and Amber Roniger Support the show

BrainStorm wants to hear from you! Send us a text. Ep 99: The Future of Alzheimer's Trials: AI, Biomarkers, and Remote Research – John Dwyer, CEO of The Global Alzheimer’s Platform In part 2 John Dwyer, CEO of the Global Alzheimer's Platform (GAP), and BrainStorm host Meryl Comer discuss transforming Alzheimer's research and clinical trials. Dwyer shares how the field is shifting toward earlier intervention and leveraging artificial intelligence to improve trial efficiency and accuracy. AI can help identify subtle disease patterns and ensure trials enroll appropriate candidates. GAP is also pioneering remote, decentralized trials that bring research into patients' homes rather than requiring frequent clinic visits, aiming to dramatically scale up participation. Dwyer also highlights proven lifestyle interventions that support cognitive health alongside pharmaceutical treatments and suggests multiple treatment approaches may soon be available. This episode of BrainStorm is sponsored by Johnson & Johnson Support the show

BrainStorm wants to hear from you! Send us a text. The quest to speed up clinical trials is personal for John Dwyer, CEO of the Global Alzheimer's Platform (GAP). A long-time UsA2 advocate, he’s been motivated by the generations of family members lost to Alzheimer's and Parkinson's disease. Dwyer shares with BrainStorm host Meryl Comer the critical challenges of NIH funding cuts by the Trump Administration, forcing many trial sites to shut down at a time of new FDA-cleared blood tests for early diagnosis.  Dwyer highlights GAP's innovations in improving the participant experience through streamlining visits, personalized feedback, and bringing mobile trials directly to small communities. This must listen episode reinforces clinical trial participation as a valuable care option while advancing research for millions affected by Alzheimer's and related dementias.  This episode of BrainStorm is sponsored by Johnson & Johnson Support the show

BrainStorm wants to hear from you! Send us a text. Diane Rehm, the legendary 89-year-old NPR talk show host, discusses her passionate advocacy for medical aid in dying with BrainStorm host, Meryl Comer. Rehm’s view was shaped by her husband John's difficult death from Parkinson's disease and the experience transformed her into a fierce advocate for end-of-life autonomy. She's adamant that if diagnosed with serious illness or early signs of Alzheimer's, she would travel to Switzerland rather than undergo treatment or lose her cognitive capacity, declaring that legislators have "no right to control my decision as to when I die." Despite confronting these weighty topics, Diane exemplifies what researchers call a "superager"—maintaining remarkable physical and cognitive health through decades of Pilates, a disciplined diet, active social engagement, and continued work. She also reflects on her storied broadcasting career, lamenting how modern media has become siloed and less committed to presenting multiple perspectives, while emphasizing her core philosophy that "a talk show should really be called a listening show"—valuing ordinary people's voices as much as those of distinguished leaders. Support the show

BrainStorm wants to hear from you! Send us a text. Dr. Rachel Buckley discusses the critical link between menopause and Alzheimer's risk in women with BrainStorm host Meryl Comer. Dr. Buckley explains that early menopause can be associated with faster cognitive decline and higher tau levels in the brain. She emphasizes the importance of timing for hormone replacement therapy and how estrogen plays a vital role in brain health through receptors that regulate communication between brain regions and mood. Dr. Buckley advocates for proactive conversations with doctors starting at age 40, midlife cognitive checkups around age 55, and better sex-specific reporting in clinical trials, noting that recent Alzheimer's treatments showed dramatically different results in men (42% benefit) versus women (12% benefit). As leader of a Welcome LEAP research team, she's working to cut women's lifetime Alzheimer's risk in half within three years, representing a new wave of prevention-focused research that coincides with the critical menopause transition period. This is a must listen episode! Support the show

BrainStorm wants to hear from you! Send us a text. Dr. Rachel Buckley of Mass General Hospital and Harvard Medical School discusses groundbreaking research revealing stark sex differences in Alzheimer's disease with BrainStorm host Meryl Comer. Her studies found that while men and women show similar levels of amyloid protein, women consistently display significantly higher levels of tau. This discovery has sparked a $50 million Welcome Leap Care grant aimed at cutting Alzheimer's lifetime risk among women by half. The episode clarifies widespread confusion about hormone replacement therapy, explaining that the problematic Women's Health Initiative study used outdated hormone formulations on women over 65—far past the optimal window for intervention. Dr. Buckley emphasizes that current evidence supports HRT use within certain parameters and stresses the importance of women advocating for themselves when experiencing perimenopause symptoms like brain fog and sleep disturbances. The research highlights menopause as a critical period that may influence Alzheimer's risk decades later. Support the show

BrainStorm wants to hear from you! Send us a text. In this deeply moving episode of BrainStorm by UsAgainstAlzheimer’s, Emma Heming Willis shares her intimate journey as a caregiver to her husband Bruce Willis, who lives with frontotemporal dementia. Their conversation covers the progression from early warning signs to diagnosis and the complex decisions required in caregiving - including the heartbreaking but necessary choice to have Bruce live separately to better serve both his needs and their children's wellbeing. Emma's candid discussion about reframing expectations, finding permission to ask for help, and discovering unexpected beauty amid profound loss offers hope and practical guidance for other caregivers. Her transformation of personal tragedy into advocacy through her book "The Unexpected Journey"  demonstrates how caregivers can find purpose and meaning while navigating one of life's most challenging experiences. You don’t want to miss this episode! Produced by Susan Quirk and Amber Roniger Support the show

BrainStorm wants to hear from you! Send us a text. In this episode of BrainStorm by UsAgainstAlzheimer’s Dr. Jonathan Rosand, co-founder of the McCance Center for Brain Health at Harvard discusses his revolutionary approach to preventing brain diseases before they start with host Meryl Comer. Dr. Rosand explains how his work originated from his experience treating severe brain injuries, where he witnessed patients and their families developing depression, anxiety, and PTSD after surviving critical care. This led him to ultimately developing the "Brain Care Score" - a tool that measures 12 daily lifestyle choices that can substantially reduce the risk of dementia, stroke, and depression. The Brain Care Score gives individuals agency over their brain health, emphasizing that prevention is about daily choices rather than complex medical interventions.  Learn more about the Brain Care Score at the McCance Center for Brain Health.  Produced by Susan Quirk and Amber Roniger Support the show

BrainStorm wants to hear from you! Send us a text. In this episode of BrainStorm by UsAgainstAlzheimer’s Dr. Carolyn Clevenger, Founder and Director of Emory's innovative Integrated Memory Care Clinic continues to explore the complex realities of Alzheimer's caregiving with host Meryl Comer. Dr. Clevenger shares her expertise on recognizing when families need additional support, managing behavioral symptoms without over-medication, and ensuring families remain central to care decisions even in residential settings. The conversation covers the often-overlooked medical causes of agitation and how to navigate the challenging transition to memory care facilities while maintaining control over your loved one's treatment. This episode offers both professional insights and compassionate guidance for families facing difficult decisions in their caregiving journey. Sponsored by Lundbeck US Produced by Susan Quirk and Amber Roniger Support the show

BrainStorm wants to hear from you! Send us a text. In this episode of BrainStorm by UsAgainstAlzheimer's, host Meryl Comer explores the critical issue of agitation in dementia care with Dr. Carolyn Clevenger, Founder and Director of Emory's Integrated Memory Care Clinic. Dr. Clevenger provides practical advice for caregivers, emphasizing that documentation of behaviors and triggers is crucial, and that caregivers must learn to adapt.  Her innovative approach to dementia care through integrated memory care which provides primary care, dementia specialist services, and family caregiver support all in one practice. This is a must listen for all caregivers!  This episode of BrainStorm is sponsored by Lundbeck US.  Support the show

BrainStorm wants to hear from you! Send us a text. Support the show

BrainStorm wants to hear from you! Send us a text. In this episode of BrainStorm, Paul Irving discusses the PBS documentary produced by Bradley Cooper called Caregiving with host Meryl Comer. Their conversation centers on the widespread impact of caregiving in America, where over 53 million people provide unpaid care for loved ones with conditions like Alzheimer's. Irving emphasizes that caregiving is a universal human experience that creates significant economic challenges, with the Milken Institute estimating losses around $1 trillion annually. Irving advocates for developing "care-aware cultures" in workplaces and society and he stresses that human capital is any organization's most important asset. This is a must listen episode for everyone.  Learn how you can share your personal story at stories@usagainstalzheimers.org. Support the show

BrainStorm wants to hear from you! Send us a text. In this episode of BrainStorm Nancy Treaster, a certified caregiving advocate and co-host of The Caregiver's Journey podcast, shares her professional and personal experiences with host Meryl Comer. Their conversation focuses on agitation, one of the most challenging aspects of dementia care, affecting more than half of all Alzheimer’s patients in terms of quality of life while increasing caregiver burden. Treaster emphasizes the importance of being a "detective" when agitation occurs and identifying potential medical triggers before exploring other causes. They also share practical coping strategies while emphasizing the critical need for caregiver self-care. Don’t miss out on the caregiving advice they share from their own lived experiences. In addition, learn how you can share your personal story at stories@usagainstalzheimers.org.  BrainStorm by UsAgainstAlzheimer's is sponsored by Lundbeck.  Support the show

BrainStorm wants to hear from you! Send us a text. In this episode of BrainStorm by UsAgainstAlzheimer's Muffy Walker, a psychiatric nurse, founder of the International Bipolar Foundation, and author of the novel "Memory Weavers" discusses how her personal experiences caring for family members with both Alzheimer's disease and mental illness inspired her advocacy work. Her novel explores experiences of one person with Alzheimer's who loses memories and another with PTSD who can't escape traumatic memories. The conversation with host Meryl Comer delves into the persistent stigma surrounding both conditions, the challenges of caregiving, advances in early diagnosis through genetic testing, and intergenerational trauma impacts. Walker highlights the importance of social connection in preventing cognitive decline and the isolation many caregivers experience as well as the valuable resources now available to patients and caregivers that weren't accessible when her mother was diagnosed 23 years ago. This is a must listen episode! Support the show

We want to hear from you! Send us a text. in this episode of the "BrainStorm" by UsAgainstAlzheimer's, George Vradenburg, Co-founder and Chairman of UsAgainstAlzheimer's, and Russ Paulsen, the organization's Chief Operating Officer, discuss the impact of the Trump administration's policies on Alzheimer's research with host Meryl Comer. The conversation highlights the systematic dismantling of the National Institutes of Health (NIH) and other critical agencies, which threatens to undermine Alzheimer's research and public health. Vradenburg and Paulsen express concerns about the lack of transparency in the reorganization and the potential negative effects on drug reviews and approvals due to significant cuts at the FDA. They highlight the importance of protecting key programs that support seniors and the potential global impact of these policy changes. Despite the challenges, both Paulsen and Vradenburg are optimism about scientific advances in diagnosing and treating Alzheimer's, including the development of blood tests and new treatments. Hear the call to action for listeners to advocate for continued support for Alzheimer's research and to contact their members of Congress to ensure that funding remains a priority. This is a must listen episode!   This episode is sponsored by Genentech. Support the show

Journalist and author Greg O'Brien, who was diagnosed with early-onset Alzheimer's over a decade ago, shares his experience of speaking in Washington D.C. at the Lincoln Memorial with BrainStorm host Meryl Comer. O'Brien delivered a speech in front of a crowd of thousands to advocate for the importance of scientific research for Alzheimer's and other diseases and protest proposed cuts to medical research funding that would affect Alzheimer's and other disease research.  This episode also includes commentary from George Vradenburg, founder and chair of UsAgainstAlzheimer's, discussing the coalition of patient advocacy organizations fighting to maintain the integrity of America's biomedical and scientific research institutions in the face of proposed budget cuts. This episode is sponsored by Genentech. Support the show