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Venereal syphilis in Colombia: Where immune-biology sets the stage for the uncontrolled spread of the disease
  • 29/11/2012
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Venereal syphilis in Colombia: Where immune-biology sets the stage for the uncontrolled spread of the disease

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Descripción de Venereal syphilis in Colombia: Where immune-biology sets the stage for the uncontrolled spread of the disease

The clinical manifestations of venereal syphilis reflect the propensity of the syphilis bacterium to disseminate and induce chronic inflammation. The appearance of the syphilitic chancre during primary syphilis typically only emerges 4 weeks after initial contact. By this time, organisms have disseminated to other organs and tissues, setting the stage for what is classically known as secondary syphilis. Paradoxically, despite the robust nature of the immune response it takes weeks to months for host defenses to gain control of the invading pathogen. Why this occurs in individuals and populations is the principal scientific objective of our global health research program.

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